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J Neuroimmunol ; 353: 577523, 2021 04 15.
Article in English | MEDLINE | ID: covidwho-1091757

ABSTRACT

OBJECTIVE: To report a unique case and literature review of post COVID-19 associated transverse myelitis and dysautonomia with abnormal MRI and CSF findings. BACKGROUND: Coronavirus disease have been reported to be associated with several neurological manifestations such as stroke, Guillain-Barré syndrome, meningoencephalitis amongst others. There are only few reported cases of transverse myelitis with the novel coronavirus (n-CoV-2) and only one reported case identifying dysautonomia in COVID-19 patient. Here, we identify a COVID-19 patient diagnosed with acute transverse myelitis in addition to dysautonomia following with complete resolution of symptoms. METHOD: A retrospective chart review of a patient diagnosed with post SARS-CoV-2 infection acute transverse myelitis and dysautonomia, and a review of literature of all the reported cases of transverse myelitis and COVID-19, from December 1st, 2019 till December 25th, 2020, was performed. CONCLUSION: To our knowledge, this is the first reported case of transverse myelitis and dysautonomia in a patient with SARS-CoV-2 infection, who responded to intravenous methyl prednisone and bromocriptine. Follow-up imaging of the spine showed complete resolution of the lesion. Further studies would be recommended to identify the underlying correlation between COVID-19 and transverse myelitis.


Subject(s)
COVID-19/complications , Myelitis, Transverse/virology , Primary Dysautonomias/virology , Spinal Cord/pathology , Adult , Anti-Inflammatory Agents/therapeutic use , Bromocriptine/therapeutic use , COVID-19/pathology , Dopamine Agonists/therapeutic use , Humans , Male , Methylprednisolone/therapeutic use , Myelitis, Transverse/drug therapy , Myelitis, Transverse/pathology , SARS-CoV-2
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